Triethylamine → HCID 22921713, compound

HRID 1756544Notes

Reaction equation

HRID 1756544 reaction equation
[Cl:1][C:2]1[CH:19]=[CH:18][C:5]2[O:6][C:7]3[CH:17]=[CH:16][CH:15]=[CH:14][C:8]=3[CH2:9][N:10]([C:11](Cl)=[O:12])[C:4]=2[CH:3]=1.CCN(CC)CC.[NH2:27][CH2:28][C:29]#[N:30]>C(Cl)Cl>[Cl:1][C:2]1[CH:19]=[CH:18][C:5]2[O:6][C:7]3[CH:17]=[CH:16][CH:15]=[CH:14][C:8]=3[CH2:9][N:10]([C:11]([NH:30][CH2:29][C:28]#[N:27])=[O:12])[C:4]=2[CH:3]=1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 10901AminoacetonitrileHCID 149759838-chlorodibenz[b,f][1,4]oxazepin-10(11H)carbonyl chloride

Product 1

HCID 22921713HCID 22921713, compoundYield 80.6%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

By the method of Example 18, the title compound of Example 2 (5.24 g, 17.8 mmol) in 100 mL of CH2Cl2 with molecular sieves #5A (10 g) and Et3N (2.5 mL, 18.0 mmol) was reacted with aminoacetonitrile (1.0 g, 17.8 mmol) to produce 4.5 g of the title product.

Sources & evidence

ORD record
ord-d977780ef5804b0aa85a43caf42a49f1
Source dataset
uspto-grants-1995_08
Patent number
US05441950

Reaction notes

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