Isatin → 2-Aminonicotinic acid

HRID 1756585Notes

Reaction equation

N1C2C(=CC=CC=2)C(=O)C1=O.[NH2:12][C:13]1[C:18]([C:19]([OH:21])=[O:20])=[CH:17][CH:16]=[C:15](F)[N:14]=1>>[NH2:12][C:13]1[N:14]=[CH:15][CH:16]=[CH:17][C:18]=1[C:19]([OH:21])=[O:20]

Participants

Reactant 2

HCID 7054Isatin

HCID 1315138786724-78-9

Product 1

HCID 729302-Aminonicotinic acid

Procedure

Using the procedure in Example 56 and substituting 5-fluoroisatin for isatin and 2-amino-6-fluoropyridine-3-carboxylic acid (Rogers et al. U.S. Pat. No. 4,383,851, 1983) for 2-aminonicotinic acid gives the title compound.

Sources & evidence

ORD record: ord-6e0eb5c4612043e5988a99a2f0d684b5
Source dataset: uspto-grants-1995_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05441955

Reaction notes

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