Isatin → 2-Aminonicotinic acid

HRID 1756586Notes

Reaction equation

HRID 1756586 reaction equation
N1C2C(=CC=CC=2)C(=O)C1=O.[NH2:12][C:13]1[N:21]=[CH:20][C:19](Cl)=[CH:18][C:14]=1[C:15]([OH:17])=[O:16].N[C@H](C(O)=O)CC>>[NH2:12][C:13]1[N:21]=[CH:20][CH:19]=[CH:18][C:14]=1[C:15]([OH:17])=[O:16]

Participants

4

Reactant 3

HCID 7054IsatinHCID 80283(-)-2-Aminobutyric acidHCID 193907282-Amino-5-chloropyridine-3-carboxylic acid

Product 1

HCID 729302-Aminonicotinic acid

Procedure

Using the procedure in Example 56 and substituting 5-fluoroisatin for isatin and 2-amino-5-chloronicotinic acid (Abu El-Haj et al., U.S. Pat. No. 3,917,624, 1975) for 2-aminonicotinic acid gives the title compound.

Sources & evidence

ORD record
ord-3146c6ebbfba4bd79266e556fded5967
Source dataset
uspto-grants-1995_08
Patent number
US05441955

Reaction notes

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