Hydrochloric Acid → HCID 19390815, compound

HRID 1756710Notes

Reaction equation

C(OC([NH:11][C:12]1[C:17](=[O:18])[N:16]([CH2:19][C:20]([NH:22][CH:23]([CH:40]([CH3:42])[CH3:41])[C:24](=[O:39])[C:25]([F:38])([F:37])[C:26](=[O:36])[NH:27][CH2:28][C:29]([O:31][C:32]([CH3:35])([CH3:34])[CH3:33])=[O:30])=[O:21])[C:15]([C:43]2[CH:48]=[CH:47][C:46]([F:49])=[CH:45][CH:44]=2)=[N:14][CH:13]=1)=O)C1C=CC=CC=1.Cl>>[NH2:11][C:12]1[C:17](=[O:18])[N:16]([CH2:19][C:20]([NH:22][CH:23]([CH:40]([CH3:42])[CH3:41])[C:24](=[O:39])[C:25]([F:37])([F:38])[C:26](=[O:36])[NH:27][CH2:28][C:29]([O:31][C:32]([CH3:35])([CH3:34])[CH3:33])=[O:30])=[O:21])[C:15]([C:43]2[CH:44]=[CH:45][C:46]([F:49])=[CH:47][CH:48]=2)=[N:14][CH:13]=1

Participants

Reactant 2

HCID 313Hydrochloric Acid

HCID 19390809HCID 19390809, compound

Product 1

HCID 19390815HCID 19390815, compound

Procedure

2-[5-Benzyloxycarbonylamino-2-(4-fluorophenyl)-6-oxo-1,6-dihydropyrimidin-1-yl]-N-[3,3-difluoro-1-isopropyl-2-oxo-3-[N-(tert-butoxycarbonylmethyl)carbamoyl]propyl]acetamide. The procedure was similar to Example 1 except that a 10% hydrochloric acid wash was done. Chromatography solvent: chloroform:methanol (40:1); TLC: Rf =0.5, chloroform:methanol (40:1); MS: m/z=688(M+1). This product is also a Compound of the invention.

Workup

washwash

Sources & evidence

ORD record: ord-882ec56c293d4f06bfe08b1709732c8c
Source dataset: uspto-grants-1995_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05441960

Reaction notes

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