反应详情

To a mixture of 2.35 g of (R)-2-(2, 3-methylenedioxyphenyl) heptylamine, 1.20 g of triethylamine and 20 ml of ethyl acetate was dropwise added 1.72 g of phenyl chloroformate with ice cooling and stirring, and the resultant mixture was stirred at room temperature for 2 hours. The reaction mixture was washed with water and saturated saline in this order, dried over anhydrous sodium sulfate and the solvent evaporated to give 3.51 g of N-phenoxycarbonyl-(R)-2-(2, 3-methylenedioxyphenyl) heptylamine.

1. washThe reaction mixture was washed with water and saturated saline in this order
2. dry with materialdried over anhydrous sodium sulfate
3. customthe solvent evaporated