2,4-Difluoroaniline → N-(2,4-difluorophenyl)-5-dodecyl-2H-tetrazole-2-acetamide

HRID 1756939Notes

Reaction equation

[CH2:1]([C:13]1[N:14]=[N:15][N:16]([CH2:18][C:19]([OH:21])=O)[N:17]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH3:12].C(C1N=NN(CC(O)=O)N=1)CCCCCCCCC.[F:41][C:42]1[CH:48]=[C:47]([F:49])[CH:46]=[CH:45][C:43]=1[NH2:44].C(C1C=CC=C(C(C)C)C=1N)(C)C>>[F:41][C:42]1[CH:48]=[C:47]([F:49])[CH:46]=[CH:45][C:43]=1[NH:44][C:19](=[O:21])[CH2:18][N:16]1[N:15]=[N:14][C:13]([CH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH3:12])=[N:17]1

Participants

Reactant 4

HCID 97092,4-Difluoroaniline

HCID 32484Diisopropylaniline

HCID 107090715-dodecyl-2H-tetrazole-2-acetic acid

HCID 214695295-decyl-2H-tetrazole-2-acetic acid

Product 1

HCID 19036057N-(2,4-difluorophenyl)-5-dodecyl-2H-tetrazole-2-acetamide

Procedure

When in the general procedure of Example 88 an appropriate amount of 5-dodecyl-2H-tetrazole-2-acetic acid was substituted for 5-decyl-2H-tetrazole-2-acetic acid and 2,4-difluoroaniline was substituted for 2,6-diisopropylaniline, the title compound was obtained, mp 103°-106° C.

Sources & evidence

ORD record: ord-7dbb3bf40347442e987d571a8f82a012
Source dataset: uspto-grants-1995_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05441975

Reaction notes

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