Water → HCID 19389481, compound

HRID 1757050Notes

Reaction equation

HRID 1757050 reaction equation
[Si:1]([O:8][CH2:9][CH:10]1[O:15][C:14](=[O:16])[CH2:13][CH:12](O)[CH2:11]1)([C:4]([CH3:7])([CH3:6])[CH3:5])([CH3:3])[CH3:2].C1(C)C=CC(S(O)(=O)=O)=CC=1.O>C1(C)C=CC=CC=1>[Si:1]([O:8][CH2:9][CH:10]1[O:15][C:14](=[O:16])[CH:13]=[CH:12][CH2:11]1)([C:4]([CH3:7])([CH3:6])[CH3:5])([CH3:3])[CH3:2]

Participants

5

Reactant 3

HCID 962WaterHCID 6101p-Toluenesulfonic acidHCID 19389468HCID 19389468, compound

Product 1

HCID 19389481HCID 19389481, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

6-t-Butyldimethylsilyloxymethyl-4-hydroxytetrahydropyran-2-one (1.0 parts) was dissolved in toluene and p-toluenesulphonic acid (0.1 parts) was added. The reaction mixture was heated at reflux with removal of water via a Dean and Stark apparatus. The cooled reaction mixture was then washed with water and evaporated to give 6-t-butyl dimethylsilyloxymethyl-5,6-dihydropyran-2-one (0.3 parts).

Workup

  1. temperatureThe reaction mixture was heated
  2. customThe cooled reaction mixture
  3. washwas then washed with water
  4. customevaporated

Sources & evidence

ORD record
ord-85bda2480f794ae9bdb4ccfc88a25294
Source dataset
uspto-grants-1995_08
Patent number
US05443970

Reaction notes

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