反应详情

A mixture of 3.59 g (8.85 mmol) of 8-(5-benzyloxy-2-pyrimidinyl)-8-aza-5-azoniaspiro [4.5]decane bromide, 1.47 g (9.73 mmol) of 4,5-dichloro-2-methylimidazole and 4.89 g (35.41mmol) of potassium carbonate in 72 ml of dimethylformamide is refluxed for 12 hours and filtered hot. The dimethylformamide is evaporated and the product is chromatographed on silica gel, yielding 2.90 g (69%) of 2-{4-[4-(4,5-dichloro-2-methylimidazol-1-yl)butyl]-1-piperazinyl}-5-benzyloxypyrimidine.

1. temperatureis refluxed for 12 hours
2. filtrationfiltered hot
3. customThe dimethylformamide is evaporated
4. customthe product is chromatographed on silica gel