Sulfuric Acid → HCID 19388006, compound

HRID 1757473Notes

Reaction equation

HRID 1757473 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:10]=[CH:11][C:12]=1[OH:13])[C:6]([O:8][CH3:9])=[O:7].[C:14]12(O)[CH2:23][CH:18]3[CH2:19][CH:20]([CH2:22][CH:16]([CH2:17]3)[CH2:15]1)[CH2:21]2.S(=O)(=O)(O)O>ClCCl>[C:14]12([C:11]3[CH:10]=[C:5]([CH:4]=[C:3]([O:2][CH3:1])[C:12]=3[OH:13])[C:6]([O:8][CH3:9])=[O:7])[CH2:23][CH:18]3[CH2:19][CH:20]([CH2:22][CH:16]([CH2:17]3)[CH2:15]1)[CH2:21]2

Participants

5

Reactant 3

HCID 1118Sulfuric AcidHCID 19844Methyl VanillateHCID 641521-Adamantanol

Product 1

HCID 19388006HCID 19388006, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

12.37 g (68 mM) of methyl 3-methoxy-4-hydroxybenzoate in 150 ml of dichloromethane are treated with 10.33 g (68 mM) of adamantanol and 3.72 ml of concentrated sulphuric acid under the conditions described in Example 9(a). After the same treatment, there are isolated 20.3 g (94.5%) of the expected derivative, of melting point 179° C.

Workup

  1. customAfter the same treatment, there are isolated 20.3 g (94.5%) of the expected derivative, of melting point 179° C.

Sources & evidence

ORD record
ord-661a63432371454181f8bffd35505c4e
Source dataset
uspto-grants-1995_08
Patent number
US05446059

Reaction notes

Loading…