Oxalic acid dihydrate → HCID 19388558, compound

HRID 1757565Notes

Reaction equation

HRID 1757565 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[NH:8][CH2:7][N:6]([CH2:12][CH2:13][N:14]([CH2:17][CH3:18])[CH2:15][CH3:16])[C:5]2=[O:19].[C:20]([OH:25])(=[O:24])[C:21]([OH:23])=[O:22].O.O>C(O)C.C(OCC)C.C(O)C>[C:20]([OH:25])(=[O:24])[C:21]([OH:23])=[O:22].[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[NH:8][CH2:7][N:6]([CH2:12][CH2:13][N:14]([CH2:17][CH3:18])[CH2:15][CH3:16])[C:5]2=[O:19]

Participants

5

Reactant 2

HCID 61373Oxalic acid dihydrateHCID 10826712HCID 10826712, compound

Product 1

HCID 19388558HCID 19388558, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 21585056Diethyl ether ethanolSolvent

Procedure

16.90 Grammes (60.0 mmoles) of 6-chloro-3-[2-(diethylamino)ethyl]-2,3-dihydro-4(1H)-quinazolinone are dissolved in 25 ml of ethyl alcohol, to which, at the temperature of 4° C., 170 ml of a solution containing 8.32 grammes (66.0 mmoles) of dihydrate oxalic acid in a mixture of ethyl ether-ethyl alcohol in the ratio 5:1 are added.

Workup

  1. additionare added

Sources & evidence

ORD record
ord-6a4a6ce3ec274e158ff7eba2c7986974
Source dataset
uspto-grants-1995_08
Patent number
US05446152

Reaction notes

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