Oxalic acid dihydrate → HCID 19388576, compound

HRID 1757567Notes

Reaction equation

HRID 1757567 reaction equation
[C:1]([OH:6])(=[O:5])[C:2]([OH:4])=[O:3].O.O.[CH2:9]([N:16]1[C:25]2[C:20](=[CH:21][C:22]([Cl:26])=[CH:23][CH:24]=2)[C:19](=[O:27])[N:18]([CH2:28][CH2:29][N:30]([CH2:33][CH3:34])[CH2:31][CH3:32])[CH2:17]1)[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1>C(OCC)C.C(O)C>[C:1]([OH:6])(=[O:5])[C:2]([OH:4])=[O:3].[CH2:9]([N:16]1[C:25]2[C:20](=[CH:21][C:22]([Cl:26])=[CH:23][CH:24]=2)[C:19](=[O:27])[N:18]([CH2:28][CH2:29][N:30]([CH2:33][CH3:34])[CH2:31][CH3:32])[CH2:17]1)[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1

Participants

4

Reactant 2

HCID 61373Oxalic acid dihydrateHCID 9820797HCID 9820797, compound

Product 1

HCID 19388576HCID 19388576, compoundYield 50%

Reagents, catalysts & solvents 1

HCID 21585056Diethyl ether ethanolSolvent

Procedure

763 Milligrammes (6.1 mmoles) of dihydrate oxalic acid dissolved in 20 ml of a mixture of ethyl ether-ethyl alcohol in a ratio of 5:1 are added to 2.00 grammes (6.1 mmoles) of 1-benzyl-6-chloro-3-[2-(diethylamino)ethyl]-2,3-dihydro-4(1H)-quinazolinone and the product, which immediately crystallizes, is recovered through filtration with a yield of 50%. The product obtained has the following chemical-physical characteristics:

Workup

  1. customthe product, which immediately crystallizes
  2. filtrationis recovered through filtration with a yield of 50%
  3. customThe product obtained

Sources & evidence

ORD record
ord-b41137e1343d47b099c3512fceafa79e
Source dataset
uspto-grants-1995_08
Patent number
US05446152

Reaction notes

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