Methyl iodide → HCID 10732515, compound

HRID 1757570Notes

Reaction equation

HRID 1757570 reaction equation
[H-].[Na+].[Cl:3][C:4]1[CH:5]=[C:6]2[C:11](=[CH:12][CH:13]=1)[NH:10][CH2:9][N:8]([CH2:14][CH2:15][N:16]1[CH2:20][CH2:19][CH2:18][CH2:17]1)[C:7]2=[O:21].[CH3:22]C(N(C)C)=O.CI>O>[Cl:3][C:4]1[CH:5]=[C:6]2[C:11](=[CH:12][CH:13]=1)[N:10]([CH3:22])[CH2:9][N:8]([CH2:14][CH2:15][N:16]1[CH2:20][CH2:19][CH2:18][CH2:17]1)[C:7]2=[O:21]

Participants

6

Reactant 4

HCID 6328Methyl iodideHCID 24758Sodium hydrideHCID 31374DimethylacetamideHCID 10850320HCID 10850320, compound

Product 1

HCID 10732515HCID 10732515, compoundYield 14%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

543 Milligrammes (22.5 mmoles) of 60% sodium hydride are added to 3.50 grammes (12.5 mmoles) of 6-chloro-2,3-dihydro-3-[2-(pyrrolidino)ethyl]-4(1H)-quinazolinone in 25 mlof anhydrous dimethylacetamide and the solution is left at room temperature, in agitation and in an inert gas atmosphere, for 30 minutes. 0.86 Ml (13.8 mmoles) of methyl iodide are slowly dripped and the reactionmixture is kept for 6 hours at room temperature. The reaction mixture is then diluted with water and ice and the product is extracted with ethyl ether and recovered through evaporation of the organic solvent, obtaining an oily substance, with a yield of 14%, presenting the following chemical-physical characteristics:

Workup

  1. waitthe reactionmixture is kept for 6 hours at room temperature
  2. extractionthe product is extracted with ethyl ether
  3. customrecovered through evaporation of the organic solvent
  4. customobtaining an oily substance

Sources & evidence

ORD record
ord-f67b6f9ca840463887ac64b16dac3f27
Source dataset
uspto-grants-1995_08
Patent number
US05446152

Reaction notes

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