Diethyl Ether → HCID 22071835, compound

HRID 1757572Notes

Reaction equation

HRID 1757572 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]([CH2:12][CH:13]1[CH2:18][CH2:17][CH2:16][CH2:15][CH2:14]1)[CH2:7][N:6]([CH2:19][CH2:20][N:21]([CH2:24][CH3:25])[CH2:22][CH3:23])[C:5]2=[O:26].C(OCC)C.[C:32]([OH:44])(=[O:43])[CH2:33][C:34]([CH2:39][C:40]([OH:42])=[O:41])([C:36]([OH:38])=[O:37])[OH:35].O>C(O)C>[C:32]([OH:44])(=[O:43])[CH2:33][C:34]([CH2:39][C:40]([OH:42])=[O:41])([C:36]([OH:38])=[O:37])[OH:35].[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]([CH2:12][CH:13]1[CH2:18][CH2:17][CH2:16][CH2:15][CH2:14]1)[CH2:7][N:6]([CH2:19][CH2:20][N:21]([CH2:24][CH3:25])[CH2:22][CH3:23])[C:5]2=[O:26]

Participants

5

Reactant 3

HCID 3283Diethyl EtherHCID 222302-Hydroxy-1,2,3-propanetricarboxylic acid hydrate (1:1)HCID 10619632HCID 10619632, compound

Product 1

HCID 22071835HCID 22071835, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

1.00 Gramme (2.7 mmoles) of 6-chloro-1-cyclohexylmethyl-3-[2(diethylamino)ethyl]-2,3-dihydro-4(1H)-quinazolinone, dissolved in 10 ml of ethyl alcohol is joined, in agitation andat the temperature of 4° C., by 10 ml of a solution of ethyl ether and ethyl alcohol in a ratio of 5:1 containing 668 milligrammes (3.2 mmoles) of monohydrate citric acid.

Sources & evidence

ORD record
ord-4d39430d316e4efcbd005282d967764f
Source dataset
uspto-grants-1995_08
Patent number
US05446152

Reaction notes

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