Hydrochloric Acid → HCID 13037315, compound

HRID 1757977Notes

Reaction equation

HRID 1757977 reaction equation
[CH2:1]([O:3][C:4]([C:6]1[N:7]=[CH:8][C:9]2[NH:10][C:11]3[C:16]([C:17]=2[CH:18]=1)=[CH:15][CH:14]=[C:13]([N+:19]([O-])=O)[CH:12]=3)=[O:5])[CH3:2].[ClH:22].[H][H]>C(O)C.[Pt](=O)=O>[ClH:22].[ClH:22].[CH2:1]([O:3][C:4]([C:6]1[N:7]=[CH:8][C:9]2[NH:10][C:11]3[C:16]([C:17]=2[CH:18]=1)=[CH:15][CH:14]=[C:13]([NH2:19])[CH:12]=3)=[O:5])[CH3:2]

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 13037306HCID 13037306, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 13037315HCID 13037315, compound

Reagents, catalysts & solvents 2

HCID 345198Adams' catalystCatalystHCID 702EthanolSolvent

Procedure

0.1 g of 7-nitro-β-carbolin-3-carboxylic acid ethyl ester is suspended in 30 ml of ethanol and, after the addition of 1 ml of 5 N hydrochloric acid, is hydrogenated at normal pressure over 25 mg of platinum dioxide until the theoretical amount of hydrogen has been absorbed. The catalyst is filtered off and washed well with warm ethanol. The filtrate is treated with active carbon and concentrated until turbidity commences. After cooling, 95 mg of 7-amino-β-carbolin-3-carboxylic acid ethyl ester dihydrochloride of melting point 270° C. (decomposition) is obtained.

Workup

  1. customhas been absorbed
  2. filtrationThe catalyst is filtered off
  3. washwashed well with warm ethanol
  4. additionThe filtrate is treated with active carbon
  5. concentrationconcentrated until turbidity commences
  6. temperatureAfter cooling

Sources & evidence

ORD record
ord-919f2f8a85b84869ac96a4d582eede1d
Source dataset
uspto-grants-1983_02
Patent number
US04371536

Reaction notes

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