Hydrochloric Acid → HCID 20510938, compound

HRID 1758131Notes

Reaction equation

HRID 1758131 reaction equation
Cl.[CH3:2][O:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[N:10]1[CH2:15][CH2:14][N:13]([CH2:16][C:17]2[NH:21][C:20](=[O:22])[NH:19][C:18]=2[C:23]([O:25]CC)=[O:24])[CH2:12][CH2:11]1.[OH-].[Li+].Cl>O>[CH3:2][O:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[N:10]1[CH2:11][CH2:12][N:13]([CH2:16][C:17]2[NH:21][C:20](=[O:22])[NH:19][C:18]=2[C:23]([OH:25])=[O:24])[CH2:14][CH2:15]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 3939Lithium HydroxideHCID 20510930HCID 20510930, compound

Product 1

HCID 20510938HCID 20510938, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

The ethyl 2,3-dihydro-5-[[4-(2-methoxyphenyl)-1-piperazinyl]methyl]-2-oxo-1H-imidazole-4-carboxylate obtained in Example 6 is dissolved in a solution of 3 equivalents of lithium hydroxide in water. The solution is allowed to stand at room temperature for 48 hours before it is neutralized carefully with 2 equivalents of hydrochloric acid. The precipitate which forms is separated by filtration and recrystallized from a mixture of ethanol and ethyl acetate to give 2,3-dihydro-5-[[4-(2-methoxyphenyl)-1-piperazinyl]methyl]-2-oxo-1H-imidazole-4-carboxylic acid.

Workup

  1. customThe precipitate which forms is separated by filtration
  2. customrecrystallized from a mixture of ethanol and ethyl acetate

Sources & evidence

ORD record
ord-2bfd376c95074c4596270ec83cc529f8
Source dataset
uspto-grants-1983_02
Patent number
US04371737

Reaction notes

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