Potassium Carbonate → HCID 20510884, compound

HRID 1758145Notes

Reaction equation

HRID 1758145 reaction equation
Cl[C:2]1[N:7]=[CH:6][C:5]([Cl:8])=[CH:4][N:3]=1.[SH:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=1[OH:16].C(=O)([O-])[O-].[K+].[K+].Cl[C:24]1[CH:29]=[CH:28][C:27]([N+:30]([O-:32])=[O:31])=[CH:26][N:25]=1>CN(C)C=O.O>[N+:30]([C:27]1[CH:28]=[CH:29][C:24]([O:16][C:11]2[CH:12]=[CH:13][CH:14]=[CH:15][C:10]=2[S:9][C:2]2[N:7]=[CH:6][C:5]([Cl:8])=[CH:4][N:3]=2)=[N:25][CH:26]=1)([O-:32])=[O:31]

Participants

7

Reactant 4

HCID 11430Potassium CarbonateHCID 70718Phenol, o-mercapto-(6CI,7CI,8CI)HCID 783082-Chloro-5-nitropyridineHCID 5906412,5-Dichloropyrimidine

Product 1

HCID 20510884HCID 20510884, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 6228DimethylformamideSolvent

Procedure

At 0°, 4.0 grams (0.027 moles) of 2,5-dichloropyrimidine is added to a mixture of 3.0 grams (0.0023 mole) 2-mercaptophenol and 7.0 grams of potassium carbonate stirring in 50 ml of dimethylformamide. After stirring overnight at room temperature, 4.0 grams of 2-chloro-5-nitropyridine is added and the mixture is heated at 80° for 4 hours. The reaction mixture is then poured into excess H2O and extracted with ethyl ether (200 ml). Washing with H2O, saturated NaHCO3, brine, drying (MgSO4), and evaporation yields the crude product.

Workup

  1. temperaturethe mixture is heated at 80° for 4 hours
  2. extractionextracted with ethyl ether (200 ml)
  3. washWashing with H2O, saturated NaHCO3, brine
  4. customdrying
  5. custom(MgSO4), and evaporation

Sources & evidence

ORD record
ord-6885d473132c42b4acb94bbec56a1227
Source dataset
uspto-grants-1983_02
Patent number
US04371736

Reaction notes

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