HRID1758205

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID25795

2,2′,2′′-[1,2,3-Propanetriyltris(oxymethylene)]tris[oxirane]

C12H20O6

结构：CCCCCCCCN1C(=O)NC2(CC(C)(C)NC(C)(C)C2)C1=O

HCID11267711

1,3,8-Triazaspiro[4.5]decane-2,4-dione, 7,7,9,9-tetramethyl-3-octyl-

C19H35N3O2

PRODUCTS

生成物

结构：CCCCCCCCN1C(=O)NC2(CC(C)(C)N(CC(O)COCC(COCC(O)CN3C(C)(C)CC4(CC3(C)C)NC(=O)N(CCCCCCCC)C4=O)OCC(O)CN3C(C)(C)CC4(CC3(C)C)NC(=O)N(CCCCCCCC)C4=O)C(C)(C)C2)C1=O

HCID20510585

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID957

1-Octanol

C8H18O

CONDITIONS

反应条件

温度: 180 °C

PROCEDURE

实验过程

A mixture of 11.0 g of 7,7,9,9-tetramethyl-3-octyl-1,3,8-triazaspiro[4.5]decane-2,4-dione and 2.6 g of glycerol tris(2,3-epoxypropyl)ether in 10 ml of octanol was heated at 180° C. for 30 hours. After completion of the reaction, the reaction mixture was purified by column chromatography through silica gel eluted with ethyl acetate, giving the desired Compound No. 349 in the form of a colourless oil. The compound had an Rf value of 0.54 on thin-layer chromatography on silica gel when developed with a 10:1 by volume mixture of ethyl acetate and triethylamine.

WORKUP

后处理

customAfter completion of the reaction
customthe reaction mixture was purified by column chromatography through silica gel
washeluted with ethyl acetate

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-a71dc88bbf9245bdb2dd4e207ba3866f
来源数据集: uspto-grants-1983_02
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04371644
来源说明: uspto-grants-1983_02

反应 SMILES

[CH3:1][C:2]1([CH3:24])[NH:21][C:20]([CH3:23])([CH3:22])[CH2:19][C:4]2([NH:8][C:7](=[O:9])[N:6]([CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH3:17])[C:5]2=[O:18])[CH2:3]1.[O:25]1[CH2:42][CH:26]1[CH2:27][O:28][CH2:29][CH:30]([CH2:36][O:37][CH2:38][CH:39]1[O:41][CH2:40]1)[O:31][CH2:32][CH:33]1[O:35][CH2:34]1>C(O)CCCCCCC>[OH:25][CH:26]([CH2:42][N:21]1[C:20]([CH3:23])([CH3:22])[CH2:19][C:4]2([NH:8][C:7](=[O:9])[N:6]([CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH3:17])[C:5]2=[O:18])[CH2:3][C:2]1([CH3:1])[CH3:24])[CH2:27][O:28][CH2:29][CH:30]([O:31][CH2:32][CH:33]([OH:35])[CH2:34][N:21]1[C:20]([CH3:23])([CH3:22])[CH2:19][C:4]2([NH:8][C:7](=[O:9])[N:6]([CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH3:17])[C:5]2=[O:18])[CH2:3][C:2]1([CH3:1])[CH3:24])[CH2:36][O:37][CH2:38][CH:39]([OH:41])[CH2:40][N:21]1[C:20]([CH3:23])([CH3:22])[CH2:19][C:4]2([NH:8][C:7](=[O:9])[N:6]([CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH3:17])[C:5]2=[O:18])[CH2:3][C:2]1([CH3:1])[CH3:24]