反应详情

A solution of 43 g of 5-methyl-2-nitrobenzyl chloride in 200 ml of ethanol is added drop-wise to a solution of 40 g of aminoacetaldehyde dimethylacetal and 40 g of triethylamine in 300 ml of ethanol at reflux temperature, and the solution is heated for 18 hours at reflux. It is then evaporated in a vacuum until dry and the residue is dissolved in ethyl acetate, and extracted several times with water. After the organic phase is dried and evaporated, the heading compound remains as a reddish oil.

1. temperatureat reflux temperature
2. temperaturethe solution is heated for 18 hours
3. temperatureat reflux
4. customIt is then evaporated in a vacuum
5. customuntil dry
6. dissolutionthe residue is dissolved in ethyl acetate
7. extractionextracted several times with water
8. customAfter the organic phase is dried
9. customevaporated