Water → HCID 131712955, compound

HRID 1758239Notes

Reaction equation

HRID 1758239 reaction equation
[C:1]1([CH3:20])[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[S:7]([NH:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=1[C:17](=O)[CH3:18])(=[O:9])=[O:8].[CH3:21][O:22][CH:23]([O:26][CH3:27])[CH2:24][NH2:25].C1(C)C(S(O)(=O)=O)=CC=CC=1.O>C1(C)C=CC=CC=1>[CH3:21][O:22][CH:23]([O:26][CH3:27])[CH2:24][N:25]=[C:17]([C:12]1[CH:13]=[CH:14][CH:15]=[CH:16][C:11]=1[NH:10][S:7]([C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][C:1]=1[CH3:20])(=[O:9])=[O:8])[CH3:18]

Participants

6

Reactant 4

HCID 962WaterHCID 69252-Methylbenzenesulfonic acidHCID 89728Aminoacetaldehyde dimethyl acetalHCID 62998541HCID 62998541, compound

Product 1

HCID 131712955HCID 131712955, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

33.8 g of o-tolylsulfonylaminoacetophenone, 13.7 g of aminoacetaldehyde dimethylacetal and 0.4 g of toluenesulfonic acid in 400 ml of toluene are boiled for 4 hours in a water separator and concentrated to dryness in vacuo.

Workup

  1. concentrationconcentrated to dryness in vacuo

Sources & evidence

ORD record
ord-1940e349f942489090c472f3e33625bf
Source dataset
uspto-grants-1983_02
Patent number
US04372956

Reaction notes

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