3-Methylxanthine → 3-Methylxanthine sodium

HRID 1758241Notes

Reaction equation

HRID 1758241 reaction equation
[CH3:1][N:2]1[C:10]2[N:9]=[CH:8][NH:7][C:6]=2[C:5](=[O:11])[NH:4][C:3]1=[O:12].[Na:13]>C(O)C>[Na:13].[CH3:1][N:2]1[C:10]2[N:9]=[CH:8][NH:7][C:6]=2[C:5](=[O:11])[NH:4][C:3]1=[O:12]

Participants

4

Reactant 2

HCID 706393-MethylxanthineHCID 5360545Sodium

Product 1

HCID 678245293-Methylxanthine sodium

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

20,8 g pulverized 3-methylxanthine was added in portions to a freshly prepared solution of 2,86 g sodium in 125 ml absolute ethanol and heated under reflux to give the 3-methylxanthine sodium salt. 17,3 g chloroacetone in 125 ml absolute ethanol was then added dropwise, and the reaction mixture was heated under reflux for four hours. After cooling, the precipitate was filtered off and then dissolved in dilute aqueous sodium hydroxide solution.

Workup

  1. temperatureheated
  2. temperatureunder reflux

Sources & evidence

ORD record
ord-670cc907bfb74a4c8a7a5427ff50b6c0
Source dataset
uspto-grants-1983_02
Patent number
US04372959

Reaction notes

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