反应详情

4-(1-Methyl-1,2,3,4-tetrazol-5-yl)sulfinylbutyl 1-methyl-1,2,3,4-tetrazol-5-yl sulfone (3.2 g) is dissolved in formic acid (30 ml), and thereto is added with stirring 30% hydrogen peroxide (2.3 g) at room temperature, and the mixture is stirred for 5 hours. Sodium hydrogensulfite is added to the mixture under ice-cooling in order to decompose excess performic acid. Water is added to the mixture and the precipitated crystals are collected by filtration and recrystallized from N,N-dimethylformamide to give 4-(1-methyl-1,2,3,4-tetrazol-5-yl)sulfonylbutyl 1-methyl-1,2,3,4-tetrazol-5-yl sulfone (2.1 g) as colorless prisms, m.p. 192°-194° C.

1. additionis added
2. temperaturecooling in order
3. filtrationthe precipitated crystals are collected by filtration
4. customrecrystallized from N,N-dimethylformamide