反应详情

1-Methyl-5-(2-pyridyl)methylthio-1,2,3,4-tetrazole (2.0 g) is dissolved in formic acid (20 ml), and thereto is added with stirring 30% hydrogen peroxide (1.3 g) at room temperature, and the mixture is stirred for 5 hours. Sodium hydrogensulfite is added to the mixture under ice-cooling in order to decompose excess performic acid. Water is added to the mixture and it is extracted with chloroform. Chloroform solution is washed with water and saturated aqueous sodium bicarbonate and dried over magnesium sulfate. After chloroform is distilled off, the residue is purified by column chromatography [Wakogel C-200, eluting agent, chloroform-methanol (50:1)] to give 1-methyl-1,2,3,4-tetrazol-5-yl 2-pyridylmethyl sulfoxide as brown liquid, nD26.5 =1.5810.

1. additionis added
2. temperaturecooling in order
3. extractionis extracted with chloroform
4. washChloroform solution is washed with water and saturated aqueous sodium bicarbonate
5. dry with materialdried over magnesium sulfate
6. distillationAfter chloroform is distilled off
7. customthe residue is purified by column chromatography [Wakogel C-200, eluting agent, chloroform-methanol (50:1)]