Formaldehyde → 1-Phenyl-1-propanone

HRID 1758578Notes

Reaction equation

HRID 1758578 reaction equation
[C:1]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1)(=[O:3])[CH3:2].[CH2:10]=O>C(O)C(C)C>[C:1]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1)(=[O:3])[CH2:2][CH3:10]

Participants

4

Reactant 2

HCID 712Formaldehyde2×HCID 7410Acetophenone2×

Product 1

HCID 71481-Phenyl-1-propanone

Reagents, catalysts & solvents 1

HCID 6560IsobutanolSolvent

Procedure

0.5 liter per hour of a mixture of acetophenone and a 30% strength solution of formaldehyde in isobutanol (the molar ratio of acetophenone to formaldehyde being 8:1) was reacted at 180° C., under 30 bar H2 pressure, in the apparatus, and over the catalyst, described in Example 1. The yield of propiophenone obtained was 52.8%, based on formaldehyde employed.

Sources & evidence

ORD record
ord-a6637c0541964cd1b0e5c20de561df1a
Source dataset
uspto-grants-1983_02
Patent number
US04374274

Reaction notes

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