3-Acetylpyridine → 1-(3-Pyridyl)-3-(dimethylamino)-2-propen-1-one

HRID 1758793Notes

Reaction equation

[C:1]([C:4]1[CH:5]=[N:6][CH:7]=[CH:8][CH:9]=1)(=[O:3])[CH3:2].CO[CH:12](OC)[N:13]([CH3:15])[CH3:14]>>[CH3:12][N:13]([CH3:15])[CH:14]=[CH:2][C:1]([C:4]1[CH:5]=[N:6][CH:7]=[CH:8][CH:9]=1)=[O:3]

Participants

Reactant 2

HCID 95893-Acetylpyridine

HCID 78373Dimethylformamide dimethyl acetal

Product 1

HCID 5670331-(3-Pyridyl)-3-(dimethylamino)-2-propen-1-one

Procedure

In accordance with Example 1, Part A, 0.1 mole of 3-acetylpyridine was reacted under reflux with a slight excess of N,N-dimethylformamide dimethylacetal; 3-dimethylamino-1-(3-pyridyl)-2-propen-1-one was isolated as a solid, m.p. 66°-67° C.

Sources & evidence

ORD record: ord-db5386161b0644728688fac5f06ff3d3
Source dataset: uspto-grants-1983_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04374988

Reaction notes

Loading…