Potassium Iodide → HCID 20225271, compound

HRID 1758991Notes

Reaction equation

HRID 1758991 reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][C:10](=[O:12])[CH3:11])=[CH:4][CH:3]=1.Br[CH2:14][C:15]([O:17][CH3:18])=[O:16].C(=O)([O-])[O-].[K+].[K+].[I-].[K+]>CC(C)=O>[C:15]([CH2:14][O:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:8][CH2:9][C:10](=[O:12])[CH3:11])=[CH:6][CH:7]=1)([O:17][CH3:18])=[O:16]

Participants

6

Reactant 4

HCID 4875Potassium IodideHCID 11430Potassium CarbonateHCID 216484-(4'-Hydroxyphenyl)-2-butanoneHCID 60984Methyl bromoacetate

Product 1

HCID 20225271HCID 20225271, compoundYield 82.6%

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

A solution of 4-(4-hydroxyphenyl) butan-2-one (16.4 g), methyl bromoacetate (15.3 g, 8.5 ml), potassium carbonate (13.8 g) and a trace of potassium iodide in acetone (200 ml) was heated under reflux for 16 hours. The solution was filtered, evaporated and the residue dissolved in ether. The ether solution was shaken successively with 2 N sodium hydroxide solution, water, dried (MgSO4) and evaporated to give the title compound as an oil (19.5 g).

Workup

  1. temperatureunder reflux for 16 hours
  2. filtrationThe solution was filtered
  3. customevaporated
  4. dissolutionthe residue dissolved in ether
  5. dry with materialdried (MgSO4)
  6. customevaporated

Sources & evidence

ORD record
ord-5d7d87913ab945bfa0bdfec0f141b7de
Source dataset
uspto-grants-1982_07
Patent number
US04338333

Reaction notes

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