Water → HCID 13067046, compound

HRID 1759198Notes

Reaction equation

HRID 1759198 reaction equation
[I-].[CH3:2][N+:3]1[C:8]([CH3:9])=[CH:7][C:6]([NH:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH3:22])=[N:5][C:4]=1[NH:23][CH2:24][CH2:25][OH:26].[OH2:27]>C([O-])(=O)C.[Ag+].CC(O)C>[C:25]([O-:26])(=[O:27])[CH3:24].[CH3:2][N+:3]1[C:8]([CH3:9])=[CH:7][C:6]([NH:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH3:22])=[N:5][C:4]=1[NH:23][CH2:24][CH2:25][OH:26]

Participants

5

Reactant 2

HCID 962WaterHCID 13067044HCID 13067044, compound

Product 1

HCID 13067046HCID 13067046, compound

Reagents, catalysts & solvents 2

HCID 11246Silver acetateCatalystHCID 3776IsopropanolSolvent

Procedure

To a solution of 1,6-dimethyl-4-(n-dodecylamino)-2-(2-hydroxyethylamino)pyrimidinium iodide (1.19 g, 0.0025 m) in a stirred mixture of water (10 ml) and 2-propanol (10 ml) at room temperature, is added silver acetate (0.44 g, 0.0026 m). An immediate yellow green precipitate forms. After allowing the stoppered mixture to stir overnight, the reaction mixture is filtered and the filtrate is concentrated under reduced pressure at room temperature to yield 1.0 g of 1,6-dimethyl-4-(n-dodecylamino)-2-(2-hydroxyethylamino)pyrimidinium acetate, m.p. 69°-74° C. with some softening at 58° C.

Workup

  1. filtrationthe reaction mixture is filtered
  2. concentrationthe filtrate is concentrated under reduced pressure at room temperature

Sources & evidence

ORD record
ord-1db9fff9dc294c1db17d307581743281
Source dataset
uspto-grants-1982_07
Patent number
US04339453

Reaction notes

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