Hydrochloric Acid → p-((1,1,2,2-Tetrafluoroethyl)thio)aniline

HRID 1759335Notes

Reaction equation

HRID 1759335 reaction equation
[F:1][C:2]([F:17])([S:6][C:7]1[CH:16]=[CH:15][C:10]([NH:11]C(=O)C)=[CH:9][CH:8]=1)[CH:3]([F:5])[F:4].Cl>O>[F:17][C:2]([F:1])([S:6][C:7]1[CH:16]=[CH:15][C:10]([NH2:11])=[CH:9][CH:8]=1)[CH:3]([F:5])[F:4]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 13038091HCID 13038091, compound

Product 1

HCID 3013935p-((1,1,2,2-Tetrafluoroethyl)thio)aniline

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of 5 g of XI and 40 ml of 6 N hydrochloric acid was heated under reflux for 4 hours. The mixture was diluted with 200 ml of water and filtered. The filtrate was concentrated to dryness and the solid residue was triturated with ether and filtered to give 4-(1,1,2,2-tetrafluoroethylthio)aniline (XII) as a hydrochloride salt.

Workup

  1. temperaturewas heated
  2. temperatureunder reflux for 4 hours
  3. filtrationfiltered
  4. concentrationThe filtrate was concentrated to dryness
  5. customthe solid residue was triturated with ether
  6. filtrationfiltered

Sources & evidence

ORD record
ord-0dd673fbf7504132b0d6ab8b94080282
Source dataset
uspto-grants-1982_07
Patent number
US04340606

Reaction notes

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