2-(Dimethylamino)ethanol → 2-Butoxy-N,N-dimethylethanamine

5.8 g (0.25 mol) sodium was added to a solution of 22 g (0.25 mol) N,N-dimethylaminoethanol in 350 ml dry toluene. After all the sodium had reacted, 35 g (0.25 mol) butyl bromide was added and the reaction mixture was subsequently refluxed for 2 hours. The reaction mixture was then cooled and washed with water. The toluene layer was extracted with dilute hydrochloric acid. The aqueous layer was subsequently rendered basic with respect to phenolphthalein and extracted with ether. The ether layer was dried and ether evaporated off. The residue was distilled. The dimethyl(2-butoxyethyl)amine obtained had a boiling point of 163°-164° C.

1. temperaturethe reaction mixture was subsequently refluxed for 2 hours
2. temperatureThe reaction mixture was then cooled
3. washwashed with water
4. extractionThe toluene layer was extracted with dilute hydrochloric acid
5. extractionextracted with ether
6. dry with materialThe ether layer was dried
7. customether evaporated off
8. distillationThe residue was distilled

ORD record

ord-7db03122962a4f64a973a6a04aa8ce2a

Source dataset

uspto-grants-1982_07

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US04340698