1,3-Propanediamine → HCID 20532009, compound

HRID 1759369Notes

Reaction equation

HRID 1759369 reaction equation
[CH2:1]([C:4]1([C:13]([C:16]([OH:18])=O)([CH3:15])[CH3:14])[C:9](=[O:10])[NH:8][C:7](=[O:11])[NH:6][C:5]1=[O:12])[CH:2]=[CH2:3].C(N1C=CN=C1)(N1C=CN=C1)=O.[NH2:31][CH2:32][CH2:33][CH2:34][NH2:35]>O1CCCC1>[CH2:1]([C:4]1([C:13]([C:16](=[O:18])[NH:31][CH2:32][CH2:33][CH2:34][NH2:35])([CH3:14])[CH3:15])[C:5](=[O:12])[NH:6][C:7](=[O:11])[NH:8][C:9]1=[O:10])[CH:2]=[CH2:3]

Participants

5

Reactant 3

HCID 4281,3-PropanediamineHCID 682631,1'-CarbonyldiimidazoleHCID 22743615HCID 22743615, compound

Product 1

HCID 20532009HCID 20532009, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

5-Allyl-5-[1-(3-aminopropylcarbamoyl)-isopropyl]barbituric acid was prepared from 2.5 g. of 5-allyl-5-(1-carboxy-isopropyl)barbituric acid, 2 g. of 1,1'-carbonyldiimidazole, 100 ml. of tetrahydrofuran and 4 g. of 1,3-diaminopropane by the above procedure. The product melted at 202°-203°.

Sources & evidence

ORD record
ord-49195f735df74a5cbfc4590a29649aee
Source dataset
uspto-grants-1982_07
Patent number
US04340736

Reaction notes

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