Acetic Acid → HCID 20514573, compound

HRID 1759408Notes

Reaction equation

HRID 1759408 reaction equation
[CH2:1]([NH:3][C:4]1[CH:5]=[CH:6][C:7]2[S:11][C:10]3=[N:12][CH2:13][CH2:14][N:9]3[C:8]=2[CH:15]=1)[CH3:2].C(O)(=O)C.[ClH:20]>CC(O)C>[ClH:20].[CH2:1]([NH:3][C:4]1[CH:5]=[CH:6][C:7]2[S:11][C:10]3=[N:12][CH2:13][CH2:14][N:9]3[C:8]=2[CH:15]=1)[CH3:2]

Participants

5

Reactant 3

HCID 176Acetic AcidHCID 313Hydrochloric AcidHCID 10262876HCID 10262876, compound

Product 1

HCID 20514573HCID 20514573, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

A stirred and warm solution of 4.5 parts of N-ethyl-2,3-dihydroimidazo[2,1-b]benzothiazol-6-amine in 30 parts of acetic acid is acidified with 2-propanol, saturated with gaseous hydrogen chloride. After cooling to room temperature, the formed hydrochloride salt is filtered off and dried at 150° C., yielding 2.1 parts of N-ethyl-2,3-dihydroimidazo[2,1-b]benzothiazol-6-amine monohydrochloride; mp. 289.2° C.

Workup

  1. filtrationthe formed hydrochloride salt is filtered off
  2. customdried at 150° C.

Sources & evidence

ORD record
ord-c2554d00578f42698aecdaf94fa74dbc
Source dataset
uspto-grants-1982_07
Patent number
US04340738

Reaction notes

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