Potassium Iodide → HCID 13046226, compound

In 100 ml dimethylformamide there is combined 34.9 g (E)-4-bromo-1,1-diethoxy-2-methyl-2-butene, 24.0 g 2,4-dichlorophenol, 40.5 g potassium carbonate and 2.37 g potassium iodide and stirred under nitrogen for about five hours. The resulting solution is poured into 500 ml deionized water and the solution extracted with two 200 ml portions diethylether which are then combined and washed first with 300 ml 10% aqueous potassium carbonate solution and then with three 400 ml portions of deionized water. The ether solution is treated with magnesium sulfate and activated charcoal then filtered. The filtrate is evaporated to dryness and the yellow-brown oil is taken up in a mixture of 120 ml acetone and 20 ml water and stirred under nitrogen as 3.0 g p-toluenesulfonic acid is added. Thirty minutes after the addition, the solution is evaporated to dryness and the residue taken up in 200 ml diethylether and this solution washed with two 200 ml portions deionized water. The ether solution is treated with magnesium sulfate and activated carbon and then filtered. The filtrate is evaporated to dryness to yield 31.47 g purple oil which is purified by chromatography on a Waters Prep. 500 LC using a silica gel cartridge yielding 25.31 g of a yellow oil. The oil is recrystallized from diethylether-hexane yielding 18.22 g solid product, m.p. 58.5°-59.5° C. Elemental Analysis. Calculated: C,53.90; H,4.11; Cl,20.93. Found: C,53.86; H,4.00; Cl,28.78.

1. additionThe resulting solution is poured into 500 ml
2. extractionthe solution extracted with two 200 ml portions diethylether which
3. washwashed first with 300 ml 10% aqueous potassium carbonate solution
4. additionThe ether solution is treated with magnesium sulfate and activated charcoal
5. filtrationthen filtered
6. customThe filtrate is evaporated to dryness
7. additionthe yellow-brown oil is taken up in a mixture of 120 ml acetone and 20 ml water
8. stirringstirred under nitrogen as 3.0 g p-toluenesulfonic acid
9. additionis added
10. additionThirty minutes after the addition
11. customthe solution is evaporated to dryness
12. washthis solution washed with two 200 ml portions
13. additionThe ether solution is treated with magnesium sulfate and activated carbon
14. filtrationfiltered
15. customThe filtrate is evaporated to dryness

ORD record

ord-5658e25f17b643c0a16dc75b5ecd0232

Source dataset

uspto-grants-1982_07

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US04340765