反应详情

A mixture of 2-acetylbenzofuran (100 g) and selenium dioxide (69.3 g) was dissolved in water (20 ml) and dioxan (500 ml) and heated under reflux for 24 h. The reaction mixture was filtered and the solvent evaporated to give a dark-red solid which was taken up in dimethylformamide and heated on a steam bath for 8 h. The solution was filtered, the solvent evaporated and the residue triturated with ether to give the title compound (65.4 g).

1. temperatureunder reflux for 24 h
2. filtrationThe reaction mixture was filtered
3. customthe solvent evaporated
4. customto give a dark-red solid which
5. temperatureheated on a steam bath for 8 h
6. filtrationThe solution was filtered
7. customthe solvent evaporated
8. customthe residue triturated with ether