Pyrrolidine → HCID 12152135, compound

HRID 1759664Notes

Reaction equation

HRID 1759664 reaction equation
Cl[C:2]1[N:7]=[C:6]([O:8][CH3:9])[C:5]([N+:10]([O-:12])=[O:11])=[CH:4][CH:3]=1.[NH:13]1[CH2:17][CH2:16][CH2:15][CH2:14]1>C(O)C>[CH3:9][O:8][C:6]1[C:5]([N+:10]([O-:12])=[O:11])=[CH:4][CH:3]=[C:2]([N:13]2[CH2:17][CH2:16][CH2:15][CH2:14]2)[N:7]=1

Participants

4

Reactant 2

HCID 31268PyrrolidineHCID 107977036-Chloro-2-methoxy-3-nitropyridine

Product 1

HCID 12152135HCID 12152135, compoundYield 98.1%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

4.79 g (0.021 mol) of 6-chloro-2-methoxy-3-nitropyridine, 40 ml of ethanol and 3.5 ml (0.042 mol) of pyrrolidine are charged to a fully equipped round-bottomed flask. The mixture is brought to reflux for 1 hour with stirring and then the mixture is cooled to ambient temperature. The product which crystallizes is filtered off and then washed with diisopropyl ether. After drying, 4.6 g of yellow powder are obtained, Yd: 96%.

Workup

  1. temperatureto reflux for 1 hour
  2. customThe product which crystallizes
  3. filtrationis filtered off
  4. washwashed with diisopropyl ether
  5. customAfter drying

Sources & evidence

ORD record
ord-05a42e53fcfa42cda0b7a2ae7c91e95e
Source dataset
uspto-grants-2005_01
Patent number
US06837908B2

Reaction notes

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