Trifluoroacetic acid → HCID 86594981, compound

HRID 1759711Notes

Reaction equation

HRID 1759711 reaction equation
[Br:1][C:2]1[CH:39]=[CH:38][C:5]2[N:6]=[C:7]([NH:9][C@H:10]([C:31]([O:33]C(C)(C)C)=[O:32])[CH2:11][C:12]3[CH:17]=[CH:16][C:15]([O:18][CH2:19][CH2:20][CH2:21][C:22](=[O:30])[NH:23][C:24]4[NH:25][CH2:26][CH2:27][CH2:28][N:29]=4)=[CH:14][CH:13]=3)[S:8][C:4]=2[CH:3]=1.C(O)(C(F)(F)F)=O>ClCCl>[Br:1][C:2]1[CH:39]=[CH:38][C:5]2[N:6]=[C:7]([NH:9][C@H:10]([C:31]([OH:33])=[O:32])[CH2:11][C:12]3[CH:17]=[CH:16][C:15]([O:18][CH2:19][CH2:20][CH2:21][C:22](=[O:30])[NH:23][C:24]4[NH:25][CH2:26][CH2:27][CH2:28][N:29]=4)=[CH:14][CH:13]=3)[S:8][C:4]=2[CH:3]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acid2×HCID 86594980HCID 86594980, compound

Product 1

HCID 86594981HCID 86594981, compoundYield 136.4%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Hydrolysis of the ester is carried out as in the previous examples, but starting from 50 mg of 8-3 and twice 0.5 ml of TFA in 1.5 ml dichloromethane. 62 mg of 8-4 is obtained (in the form of the trifluoroacetic acid salt).

Sources & evidence

ORD record
ord-918e883650ab4d69b53ec76231918aed
Source dataset
uspto-grants-2005_01
Patent number
US06838453B2

Reaction notes

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