Hydrochloric Acid → HCID 17947527, compound

HRID 1760203Notes

Reaction equation

HRID 1760203 reaction equation
[NH2:1][C:2]1[CH:3]=[CH:4][C:5]([O:8][CH3:9])=[N:6][CH:7]=1.Cl.[NH2:11][C:12]1[C:13]([Cl:19])=[N:14][CH:15]=[N:16][C:17]=1[Cl:18].C(O)C>O>[ClH:18].[CH3:9][O:8][C:5]1[N:6]=[CH:7][C:2]([NH:1][C:17]2[C:12]([NH2:11])=[C:13]([Cl:19])[N:14]=[CH:15][N:16]=2)=[CH:3][CH:4]=1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 702EthanolHCID 794345-Amino-4,6-dichloropyrimidineHCID 811216-Methoxy-3-pyridinylamine

Product 1

HCID 17947527HCID 17947527, compoundYield 72%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

5-Amino-2-methoxypyridine (8.7 g, 70.1 mmol) and conc. hydrochloric acid (1.5 ml) were added successively to a suspension of 5-amino-4,6-dichloropyrimidine (10.0 g, 45.2 mmol, produced by Tokyo Kasei Co., Ltd.) in water (100 ml)/ethanol (15 ml) at room temperature, and the mixture was heated under reflux for 3 hours. After cooling as it was, the resulting solid was collected by filtration, washed with water and air-dried at 50° C., to give the title compound (6.6 g, 72%) as a reddish brown solid.

Workup

  1. temperaturethe mixture was heated
  2. temperatureunder reflux for 3 hours
  3. temperatureAfter cooling as it
  4. filtrationthe resulting solid was collected by filtration
  5. washwashed with water
  6. customair-dried at 50° C.

Sources & evidence

ORD record
ord-f36497613ea14457a3687985f7b09dc2
Source dataset
uspto-grants-2005_01
Patent number
US06841549B1

Reaction notes

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