HCID 12136946, compound → HCID 12136947, compound

HRID 1760213Notes

Reaction equation

HRID 1760213 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([C:8]2[N:9]([C:18]3[CH:19]=[N:20][C:21]([O:24]C)=[CH:22][CH:23]=3)[C:10]3[CH:15]=[CH:14][N:13]=[C:12]([NH2:16])[C:11]=3[N:17]=2)[CH:5]=[CH:6][CH:7]=1>Cl>[NH2:16][C:12]1[C:11]2[N:17]=[C:8]([C:4]3[CH:5]=[CH:6][CH:7]=[C:2]([F:1])[CH:3]=3)[N:9]([C:18]3[CH:23]=[CH:22][C:21](=[O:24])[NH:20][CH:19]=3)[C:10]=2[CH:15]=[CH:14][N:13]=1

Participants

3

Reactant 1

HCID 12136946HCID 12136946, compound

Product 1

HCID 12136947HCID 12136947, compoundYield 43%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Conditions

Temperature
110 °C

Procedure

A mixture of 2-(3-fluorophenyl)-1-(6-methoxy-3-pyridyl)-1H-imidazo[4,5-clpyridine-4-amine (290 mL) obtained in Example 42 and conc. hydrochloric acid (10 mL) was stirred at 110° C. for 7.5 hours. The reaction solution was evaporated, and the residue was purified by NH-form silica gel column chromatography, to give the title compound (120 mg, 43%)

Workup

  1. customThe reaction solution was evaporated
  2. customthe residue was purified by NH-form silica gel column chromatography

Sources & evidence

ORD record
ord-5384b1403eb94f78a5d82f8b840c81c0
Source dataset
uspto-grants-2005_01
Patent number
US06841549B1

Reaction notes

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