Hydrochloric Acid → HCID 178508634, compound

HRID 1760222Notes

Reaction equation

HRID 1760222 reaction equation
C[O:2][C:3]1[N:8]=[CH:7][C:6]([N:9]2[C:17]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][N:19]=3)=[N:16][C:15]3[C:10]2=[N:11][CH:12]=[N:13][C:14]=3[NH2:24])=[CH:5][CH:4]=1.Cl>>[NH2:24][C:14]1[N:13]=[CH:12][N:11]=[C:10]2[C:15]=1[N:16]=[C:17]([C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][N:19]=1)[N:9]2[C:6]1[CH:5]=[CH:4][C:3]([OH:2])=[N:8][CH:7]=1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 12136956HCID 12136956, compound

Product 1

HCID 178508634HCID 178508634, compoundYield 23%

Conditions

Temperature
105 °C

Procedure

A mixture of 350 mg of 9-(6-methoxy-3-pyridyl)-8-(2-pyridyl)-9H-6-purineamine and 6 mL conc. aqueous hydrochloric acid was stirred at 105° C. for 1 hour and 45 minutes. From the resulting yellowish brown oily material, the solvent was evaporated, whereby yellowish brown crystals were obtained. The resulting crystals were collected by filtration with ethanol, to give 77 mg of the title compound as brown crystals (23% y.).

Workup

  1. customFrom the resulting yellowish brown oily material, the solvent was evaporated
  2. customwhereby yellowish brown crystals were obtained
  3. filtrationThe resulting crystals were collected by filtration with ethanol

Sources & evidence

ORD record
ord-f5015619cff14d2bab9385986ecbbc14
Source dataset
uspto-grants-2005_01
Patent number
US06841549B1

Reaction notes

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