Ethyl Thioglycolate → HCID 54725334, compound

HRID 1760492Notes

Reaction equation

HRID 1760492 reaction equation
C(O[C:4]([C:6]1[C:11](=O)[NH:10][C:9]([S:13][CH3:14])=[N:8][C:7]=1[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)=[O:5])C.O=P(Cl)(Cl)Cl.[SH:26][CH2:27][C:28]([O:30][CH2:31][CH3:32])=[O:29]>CCCCCCC.C(OCC)(=O)C>[OH:5][C:4]1[C:6]2[C:7]([C:15]3[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=3)=[N:8][C:9]([S:13][CH3:14])=[N:10][C:11]=2[S:26][C:27]=1[C:28]([O:30][CH2:31][CH3:32])=[O:29]

Participants

5

Reactant 3

HCID 12185Ethyl ThioglycolateHCID 24813Phosphorus oxychlorideHCID 136116400HCID 136116400, compound

Product 1

HCID 54725334HCID 54725334, compound

Reagents, catalysts & solvents 1

HCID 21899848Ethylacetate heptaneSolvent

Procedure

Treatment of 5-ethyloxycarbonyl-2-methylthio-4-phenyl-6-oxopyrimidine (63 mg) with POCl3 (304 μl) and subsequent reaction of the product with ethyl 2-mercaptoacetate were performed according to the methods described in example 1. The pure title compound was obtained after chromatography on silicagel in heptane/ethyl acetate 100/0=>60/40 (v/v) as eluent.

Sources & evidence

ORD record
ord-e04f01ddcb9548cdaf5f60a3c46246f3
Source dataset
uspto-grants-2005_01
Patent number
US06841553B2

Reaction notes

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