HCID 21912048, compound → HCID 20745818, compound

HRID 1760694Notes

Reaction equation

HRID 1760694 reaction equation
[Cl:1][C:2]1[CH:24]=[C:23]([CH3:25])[C:5]([O:6][C:7]2[N:15]=[C:14]([CH3:16])[CH:13]=[C:12]([NH:17][CH:18]([CH2:21]O)[CH2:19][CH3:20])[C:8]=2C(O)=O)=[C:4]([CH3:26])[CH:3]=1.ClC(Cl)([O:30][C:31](=[O:37])OC(Cl)(Cl)Cl)Cl.C[CH2:40][N:41](CC)CC>C1COCC1>[Cl:1][C:2]1[CH:3]=[C:4]([CH3:26])[C:5]([O:6][C:7]2[N:15]=[C:14]([CH3:16])[CH:13]=[C:12]([N:17]3[C@@H:18]([CH2:19][CH3:20])[CH2:21][O:30][C:31]3=[O:37])[C:8]=2[C:40]#[N:41])=[C:23]([CH3:25])[CH:24]=1

Participants

4

Reactant 2

HCID 21912048HCID 21912048, compoundHCID 86584328HCID 86584328, compound

Product 1

HCID 20745818HCID 20745818, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The title compound was prepared by reacting with 2-(4-chloro-2,6-dimethyl-phenoxy)-4-(1-hydroxymethyl-propylamino)-6-methyl-nicotinic acid with triphosgene/NEt3 in THF. 1H NMR(CDCl3) d 7.18(s,1H), 7.06(s,2H), 5.00(m,1H), 4.64(t,1H), 4.23(dd,1H), 2.339-s,3H), 2.08(s,6H). 1.5-1.8(m,2H), 0.949t,3H) ppm.

Sources & evidence

ORD record
ord-24a3766d726f4f84836088700a9850b5
Source dataset
uspto-grants-2005_01
Patent number
US06844351B1

Reaction notes

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