Water → 6-[2-(2,3-Dihydro-1,4-benzothiazin-4-yl)ethoxy]cyanonaphthalene

HRID 1760927Notes

Reaction equation

HRID 1760927 reaction equation
CS([O:5][CH2:6][CH2:7][N:8]1[C:13]2[CH:14]=[CH:15][CH:16]=[CH:17][C:12]=2[S:11][CH2:10][CH2:9]1)(=O)=O.O[C:19]1[CH:28]=[CH:27][C:26]2[C:21](=[CH:22][CH:23]=[C:24](C#N)[CH:25]=2)[CH:20]=1.C(=O)([O-])[O-].[K+].[K+].O.[CH3:38][N:39](C)C=O>>[S:11]1[C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[N:8]([CH2:7][CH2:6][O:5][C:28]2[CH:27]=[C:26]3[C:21](=[CH:20][CH:19]=2)[C:22]([C:38]#[N:39])=[CH:23][CH:24]=[CH:25]3)[CH2:9][CH2:10]1

Participants

6

Reactant 5

HCID 962WaterHCID 6228DimethylformamideHCID 11430Potassium CarbonateHCID 45894766-Hydroxy-2-naphthonitrileHCID 99216342-(3,4-dihydro-2H-benzo[b][1,4]thiazin-4-yl)ethyl methanesulfonate

Product 1

HCID 225939256-[2-(2,3-Dihydro-1,4-benzothiazin-4-yl)ethoxy]cyanonaphthaleneYield 72%

Conditions

Temperature
80 °C

Procedure

A mixture of 2-(2,3-dihydro-1,4-benzothiazin-4-yl)ethyl methanesulfonate (0.49 g, 1.82 mmol), 2-hydroxy-6-cyanonaphthalene (0.28, 1.65 mmol) and potassium carbonate (1.15 g, 8.28 mmol) in dry dimethyl formamide (15 mL) was stirred at 80° C. for 12 h. Water (50 mL) was added and extracted with ethyl acetate (2×25 mL). The combined ethyl acetate layer was washed with water (25 mL), brine (20 mL), dried (Na2SO4), filtered and the solvent was evaporated under reduced pressure. The residue was chromatographed over silica gel using a mixture of ethyl acetate and pet. ether to afford the title compound (0.41 g, 72%) as a pale yellow solid. mp: 94-96° C.

Workup

  1. extractionextracted with ethyl acetate (2×25 mL)
  2. washThe combined ethyl acetate layer was washed with water (25 mL), brine (20 mL)
  3. dry with materialdried (Na2SO4)
  4. filtrationfiltered
  5. customthe solvent was evaporated under reduced pressure
  6. customThe residue was chromatographed over silica gel using
  7. additiona mixture of ethyl acetate and pet. ether

Sources & evidence

ORD record
ord-d8b4657a5a6c4e138057bfbf198f4728
Source dataset
uspto-grants-2005_01
Patent number
US06846824B2

Reaction notes

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