L-Phenylalanine → HCID 11214348, compound

HRID 1760998Notes

Reaction equation

[CH:1]([C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([CH:10]([CH3:12])[CH3:11])[C:5]=1[N:13]=[C:14]=[O:15])([CH3:3])[CH3:2].[NH2:16][C@H:17]([C:25]([OH:27])=O)[CH2:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1.[CH2:28]([O:30][C:31]([CH:33]1[CH2:38][CH2:37][NH:36][CH2:35][CH2:34]1)=[O:32])[CH3:29]>>[CH2:18]([C@H:17]([NH:16][C:14]([NH:13][C:5]1[C:6]([CH:10]([CH3:11])[CH3:12])=[CH:7][CH:8]=[CH:9][C:4]=1[CH:1]([CH3:2])[CH3:3])=[O:15])[C:25]([N:36]1[CH2:37][CH2:38][CH:33]([C:31]([O:30][CH2:28][CH3:29])=[O:32])[CH2:34][CH2:35]1)=[O:27])[C:19]1[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=1

Participants

Reactant 3

HCID 6140L-Phenylalanine

HCID 70770Ethyl 4-piperidinecarboxylate

HCID 922592,6-Diisopropylphenyl isocyanate

Product 1

HCID 11214348HCID 11214348, compound

Procedure

This compound was prepared in two steps from 2,6-diisopropylphenylisocyanate, (L)-phenylalanine, and 4-ethoxycarbonylpiperidine in the manner previously described in General Procedure A to give the desired urea amide product as a white solid. MS: 508 [M+H]+

Sources & evidence

ORD record: ord-0e83d1fe751b477581d7fd6cf556628d
Source dataset: uspto-grants-2005_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06846836B2

Reaction notes

Loading…