反应详情

A mixture of 2-bromomethyl-4-methoxy-benzoic acid methyl ester (1.0 g, 3.9 mmol), triethylamine (391 mg, 3.9 mmol) and 2-methoxy-ethylamine (348 mg, 4.6 mmol) was heated under reflux for 2 h. After cooling to RT the mixture was filtered and evaporated. The residue was purified by chromatography (SiO2, Heptane:EtOAc 1:1 to EtOAc) to afford the title product (260 mg, 30%) as a light yellow solid. MS m/e=221.3 (M+).

1. temperaturewas heated
2. temperatureunder reflux for 2 h
3. filtrationwas filtered
4. customevaporated
5. customThe residue was purified by chromatography (SiO2, Heptane:EtOAc 1:1 to EtOAc)