Saccharin → HCID 14303125, compound

HRID 1761386Notes

Reaction equation

HRID 1761386 reaction equation
[Cl:1][C:2]1[CH:25]=[CH:24][C:5]([O:6][CH2:7][C:8]([C:11]2([CH3:23])[S:15][CH2:14][CH:13]([CH2:16][N:17]3[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18]3)[O:12]2)([CH3:10])[CH3:9])=[CH:4][CH:3]=1.[S:26]1([C:37]2[C:32](=[CH:33][CH:34]=[CH:35][CH:36]=2)[C:30](=[O:31])[NH:29]1)(=[O:28])=[O:27]>O1CCCC1>[S:26]1([C:37]2[C:32](=[CH:33][CH:34]=[CH:35][CH:36]=2)[C:30](=[O:31])[NH:29]1)(=[O:27])=[O:28].[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:6][CH2:7][C:8]([C:11]2([CH3:23])[S:15][CH2:14][CH:13]([CH2:16][N:17]3[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18]3)[O:12]2)([CH3:10])[CH3:9])=[CH:24][CH:25]=1

Participants

4

Reactant 2

HCID 5143SaccharinHCID 13454228HCID 13454228, compound

Product 1

HCID 14303125HCID 14303125, compoundYield 99.4%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

96 g (0.025 mol) of 2-[1-(4-chlorophenoxy)-2-methyl-prop-2-yl]-2-methyl-5-(piperidin-1-yl-methyl)-1,3-oxathiolane are dissolved in 40 ml of tetrahydrofuran together with 4.6 g (0.025 mol) of saccharine. The solvent is removed in vacuo and the residue is dried under a high vacuum. 14.1 g (98% of theory) of 2-[1-(4-chlorophenoxy)-2-methyl-prop-2-yl]-2-methyl-5-(piperidin-1-yl-methyl)1,3-oxathiolane saccharine salt are obtained as an amorphous substance.

Workup

  1. customThe solvent is removed in vacuo
  2. customthe residue is dried under a high vacuum

Sources & evidence

ORD record
ord-8e6c9ddfe58841f2ad62aa352ae84c9c
Source dataset
uspto-grants-1989_05
Patent number
US04826836

Reaction notes

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