Dichloromethane → HCID 14280602, compound

HRID 1761442Notes

Reaction equation

[S:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[C:3]([N:10]2[CH2:15][CH2:14][N:13]([CH2:16][CH2:17][CH2:18][O:19][N:20]3[C:29](=O)[CH2:28][C:23]4([CH2:27][CH2:26][CH2:25][CH2:24]4)[CH2:22][CH:21]3[OH:31])[CH2:12][CH2:11]2)=[N:2]1.FC(F)(F)C(O)=O.C([SiH](CC)CC)C.C(Cl)[Cl:47]>>[ClH:47].[S:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[C:3]([N:10]2[CH2:15][CH2:14][N:13]([CH2:16][CH2:17][CH2:18][O:19][N:20]3[CH2:29][CH2:28][C:23]4([CH2:27][CH2:26][CH2:25][CH2:24]4)[CH2:22][C:21]3=[O:31])[CH2:12][CH2:11]2)=[N:2]1

Participants

Reactant 4

HCID 6344Dichloromethane

HCID 6422Trifluoroacetic acid

HCID 12052Triethylsilane

HCID 14280605HCID 14280605, compound

Product 1

HCID 14280602HCID 14280602, compound

Procedure

To a solution prepared from 8-[3-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]propyloxy]-7-hydroxy-8-azaspiro[4.5]decan-9-one (4.7 g), 80 ml of CH2Cl2 and 40 ml of trifluoroacetic acid was added triethylsilane (1.8 ml) dropwise. The mixture was stirred at room temperature. After 1.5 hours, no starting material remained as judged by TLC.

Sources & evidence

ORD record: ord-86e595698d364188af49fae21b70ed73
Source dataset: uspto-grants-1989_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04826846

Reaction notes

Loading…