Diketene → HCID 131715933, compound

HRID 1761449Notes

Reaction equation

HRID 1761449 reaction equation
[CH2:1]=[C:2]1[O:6][C:4](=[O:5])[CH2:3]1.[N:7]1([CH2:13][CH2:14][OH:15])[CH2:12][CH2:11][CH2:10][CH2:9][CH2:8]1>C(N(CC)CC)C>[N:7]1([CH2:13][CH2:14][OH:15])[CH2:12][CH2:11][CH2:10][CH2:9][CH2:8]1.[C:4]([O-:5])(=[O:15])[CH2:3][C:2]([CH3:1])=[O:6]

Participants

4

Reactant 2

HCID 12661DiketeneHCID 18232N-Piperidinoethanol

Product 1

HCID 131715933HCID 131715933, compound

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

Diketene (8.1 ml) was added dropwise to 2-piperidinoethanol (9.36 ml) and triethylamine (0.05 ml) under stirring, so as to keep the temperature at 60°-70° C. (exothermic reaction). When the addition was over, the mixture was stirred at 80° for 40'. 12.4 g of the product were obtained by vacuum (2 mmHg) distillation. The NMR spectrum was in agreement.

Workup

  1. customat 60°-70° C.
  2. custom(exothermic reaction)
  3. additionWhen the addition
  4. stirringwas stirred at 80° for 40'

Sources & evidence

ORD record
ord-225ff68748c043408501038139a31dfe
Source dataset
uspto-grants-1989_05
Patent number
US04826856

Reaction notes

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