Diethylamine → HCID 13770164, compound

HRID 1761466Notes

Reaction equation

HRID 1761466 reaction equation
[Br:1][C:2]1[NH:16][C:15]2[C:17]3[C:3]=1[CH2:4][C@@H:5]1[C:10]([C:11]=3[CH:12]=[CH:13][CH:14]=2)=[CH:9][C@H:8]([NH2:18])[CH2:7][N:6]1[CH3:19].[C:20]([N:27]1[CH:31]=[CH:30]N=[CH:28]1)(N1C=CN=C1)=[S:21].[CH2:32](NCC)C>>[Br:1][C:2]1[NH:16][C:15]2[C:17]3[C:3]=1[CH2:4][C@@H:5]1[C:10]([C:11]=3[CH:12]=[CH:13][CH:14]=2)=[CH:9][C@H:8]([NH:18][C:20](=[S:21])[N:27]([CH2:31][CH3:30])[CH2:28][CH3:32])[CH2:7][N:6]1[CH3:19]

Participants

4

Reactant 3

HCID 8021DiethylamineHCID 802641,1'-ThiocarbonyldiimidazoleHCID 70359114HCID 70359114, compound

Product 1

HCID 13770164HCID 13770164, compound

Procedure

By reaction of 656 mg of 2-bromo-9,10-didehydro-6-methylergoline-8α-amine (1.5 mmol) with 1,1'-thiocarbonyldiimidazole and diethylamine, as described in Example 11, 535 mg of 3-(2-bromo-9,10-didehydro-6-methyl-8α-ergolinyl)-1,1-diethylthiourea is obtained.

Sources & evidence

ORD record
ord-2f0e1a80994848f39d5da5016879499f
Source dataset
uspto-grants-1989_05
Patent number
US04826852

Reaction notes

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