Hydrogen Bromide → HCID 178419604, compound

HRID 1761510Notes

Reaction equation

HRID 1761510 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8](O)[C:9]2[CH:22]=[CH:21][C:12]3[NH:13][C:14]([NH:16][C:17](=[O:20])[O:18][CH3:19])=[N:15][C:11]=3[CH:10]=2)=[CH:4][CH:3]=1.[BrH:24]>C(O)(=O)C>[BrH:24].[Br:24][CH:8]([C:5]1[CH:6]=[CH:7][C:2]([F:1])=[CH:3][CH:4]=1)[C:9]1[CH:22]=[CH:21][C:12]2[NH:13][C:14]([NH:16][C:17](=[O:20])[O:18][CH3:19])=[N:15][C:11]=2[CH:10]=1

Participants

4

Reactant 2

HCID 260Hydrogen BromideHCID 178502029HCID 178502029, compound

Product 1

HCID 178419604HCID 178419604, compoundYield 99.9%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A solution of 6.3 parts of methyl [5-[(4-fluorophenyl)hydroxymethyl]-1H-benzimidazol-2-yl]carbamate in 60 parts of acetic acid, saturated with hydrogen bromide was stirred for 3 hours at room temperature. The reaction mixture was evaporated, yielding 9.18 parts (99.9%) of methyl [5-[bromo(4-fluorophenyl)methyl]-1H-benzimidazol-2-yl]carbamate monohydrobromide as a residue (int. 2).

Workup

  1. customThe reaction mixture was evaporated

Sources & evidence

ORD record
ord-0028ef86884c4caf9e3f7d5cd0da10dc
Source dataset
uspto-grants-1989_05
Patent number
US04826862

Reaction notes

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