反应详情

To a mixture containing 20 g of CuI and 50 ml of tetrahydrofuran (THF) are added 105 ml of methyllithium dropwise during with agitation in a nitrogen atmosphere at a temperature of 0° C. or lower until the yellow precipitate barely dissolves. Then 8.7 g of 4-(2,6-dimethylphenyl)-3-buten-2-one in 50 ml of THF are added slowly at 0° C. The stirring is continued for an additional 2 h with a gradual increase of the temperature to +25° C. The reaction mixture obtained is hydrolysed with 300 ml of a solution of NH4Cl. The ether layer is removed, dried and evaporated to give the crude product.

1. dissolutionlower until the yellow precipitate barely dissolves
2. temperaturewith a gradual increase of the temperature to +25° C
3. customThe reaction mixture obtained
4. customThe ether layer is removed
5. customdried
6. customevaporated