反应详情

温度

95 °C

A 2 liter three necked flask fitted with a mechanical stirrer, theromometer and condenser is charged with 180 g of 4-hydroxypiperidine, 74.4 g of 4-fluorobenzaldehyde, 1 ml of Aliquot 336, 750 ml of dimethylsulfoxide and 82.8 g of anhydrous potassium carbonate. The mixture is heated at 95° C. for three days, then the product mixture is cooled and poured into 3 liters of ice water. The resultant solid precipitate is filtered, washed with water, and vacuum dried. The crude product is recrystallized from toluene, m.p. 115°-118° C.

1. temperaturethe product mixture is cooled
2. filtrationThe resultant solid precipitate is filtered
3. washwashed with water, and vacuum
4. customdried
5. customThe crude product is recrystallized from toluene, m.p. 115°-118° C.