Sodium → HCID 178461713, compound

HRID 1761835Notes

Reaction equation

[CH3:1][C@@H:2]([C@@H:14]1[C@@:18]2([CH3:35])[C@@H:19]([OH:34])[CH2:20][C@@H:21]3[C@@:26]4([CH3:32])[CH2:27][CH2:28][C@@H:29]([OH:31])[CH2:30][C@H:25]4[CH2:24][C@@H:23]([OH:33])[C@H:22]3[C@@H:17]2[CH2:16][CH2:15]1)[CH2:3][CH2:4][C:5]([NH:7][CH2:8][CH2:9][S:10]([O-:13])(=[O:12])=[O:11])=[O:6].[Na+:36].[Na].[CH:38]1[C:39]([NH2:52])=[N+:40]([O-:51])[C:41]([NH2:50])=[N:42][C:43]=1[N:44]1[CH2:49][CH2:48][CH2:47][CH2:46][CH2:45]1>>[CH:38]1[C:39]([NH2:52])=[N+:40]([O-:51])[C:41]([NH2:50])=[N:42][C:43]=1[N:44]1[CH2:49][CH2:48][CH2:47][CH2:46][CH2:45]1.[CH3:1][C@@H:2]([C@@H:14]1[C@@:18]2([CH3:35])[C@@H:19]([OH:34])[CH2:20][C@@H:21]3[C@@:26]4([CH3:32])[CH2:27][CH2:28][C@@H:29]([OH:31])[CH2:30][C@H:25]4[CH2:24][C@@H:23]([OH:33])[C@H:22]3[C@@H:17]2[CH2:16][CH2:15]1)[CH2:3][CH2:4][C:5]([NH:7][CH2:8][CH2:9][S:10]([O-:13])(=[O:11])=[O:12])=[O:6].[Na+:36]

Participants

Reactant 3

HCID 5360545Sodium

HCID 23666345Sodium Taurocholate

HCID 178507853HCID 178507853, compound

Product 1

HCID 178461713HCID 178461713, compound

Procedure

Taurocholic acid, sodium salt, was converted to a free acid form by the procedure of Example 11. About 100 mg by weight of the free acid form was mixed with 20 mg of dry minoxidil in 1 ml pH 5.5 buffer, yielding a clear solution with a final minoxidil concentration of about 2% by weight. Stirring was continued until a clear solution was obtained, after which the pH of the solution was readjusted to 5.0. No crystals were observed on examination of the composition with a polarizing microscope.

Sources & evidence

ORD record: ord-51b751c6cc6e4b42a8bb07debfb06d2b
Source dataset: uspto-grants-1989_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04828837

Reaction notes

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